Mass spectrometry‐based protein–protein interaction networks for the study of human diseases
A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …
expediting the development of novel therapeutic interventions. Disease mechanisms are …
Proteomics of the Heart
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …
Loss of protein phosphatase 1 regulatory subunit PPP1R3A promotes atrial fibrillation
KM Alsina, M Hulsurkar, S Brandenburg… - Circulation, 2019 - Am Heart Assoc
Background: Abnormal calcium (Ca2+) release from the sarcoplasmic reticulum (SR)
contributes to the pathogenesis of atrial fibrillation (AF). Increased phosphorylation of 2 …
contributes to the pathogenesis of atrial fibrillation (AF). Increased phosphorylation of 2 …
Protein Phosphatase 2A Regulates Cardiac Na+ Channels
Rationale: Voltage-gated Na+ channel (I Na) function is critical for normal cardiac
excitability. However, the Na+ channel late component (I Na, L) is directly associated with …
excitability. However, the Na+ channel late component (I Na, L) is directly associated with …
Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases
Introduction Abnormal calcium signaling between organelles such as the sarcoplasmic
reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium …
reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium …
Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders
Regulation of cell-to-cell communication in the heart by the gap junction protein Connexin43
(Cx43) involves modulation of Cx43 phosphorylation state by protein kinases, and …
(Cx43) involves modulation of Cx43 phosphorylation state by protein kinases, and …
Phosphorylation-dependent interactome of ryanodine receptor type 2 in the heart
Background Hyperphosphorylation of the calcium release channel/ryanodine receptor type
2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial …
2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial …
[HTML][HTML] PFOS disrupts key developmental pathways during hiPSC-derived cardiomyocyte differentiation in vitro
N Davidsen, L Ramhøj, I Kugathas, B Evrard… - Toxicology in Vitro, 2022 - Elsevier
Exposure to perfluorooctanesulfonic acid (PFOS) has been associated with congenital heart
disease (CHD) and decreased birth weight. PFOS exposure can disrupt signaling pathways …
disease (CHD) and decreased birth weight. PFOS exposure can disrupt signaling pathways …
Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities
Protein phosphatases have emerged as critical regulators of phosphoprotein homeostasis in
settings of health and disease. Protein phosphatase 2A (PP2A) encompasses a large …
settings of health and disease. Protein phosphatase 2A (PP2A) encompasses a large …
Molecular Role of Protein Phosphatases in Alzheimer's and Other Neurodegenerative Diseases
Alzheimer's disease (AD) is distinguished by the gradual loss of cognitive function, which is
associated with neuronal loss and death. Accumulating evidence supports that protein …
associated with neuronal loss and death. Accumulating evidence supports that protein …