Recent developments for the deuterium and tritium labeling of organic molecules
Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …
Deuterium in drug discovery: progress, opportunities and challenges
Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …
neutron to a molecule. Despite being a subtle change, this structural modification, known as …
Caveat fluorophore: an insiders' guide to small-molecule fluorescent labels
JB Grimm, LD Lavis - Nature Methods, 2022 - nature.com
The last three decades have brought a revolution in fluorescence microscopy. The
development of new microscopes, fluorescent labels and analysis techniques has pushed …
development of new microscopes, fluorescent labels and analysis techniques has pushed …
Hybrid small-molecule/protein fluorescent probes
M Minoshima, SI Reja, R Hashimoto, K Iijima… - Chemical …, 2024 - ACS Publications
Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …
localization and function in living cells. These hybrid probes are constructed by diverse site …
Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation
Autophagy is a catabolic pathway required for the recycling of cytoplasmic materials. To
define the mechanisms underlying autophagy it is critical to quantitatively characterize the …
define the mechanisms underlying autophagy it is critical to quantitatively characterize the …