The very chemical structure of DNA that enables biological heredity and evolution has non‐
trivial implications for the self‐organization of DNA molecules into larger assemblies and …

In mammals, CENP-A, a histone H3 variant found in the centromeric chromatin, is critical for
faithful chromosome segregation and genome integrity maintenance through cell divisions …

The associative memory, water-mediated, structure and energy model (AWSEM) has been
successfully used to study protein folding, binding, and aggregation problems. In this work …

Chromosome instability is a critical event in cancer progression. Histone H3 variant CENP-A
plays a fundamental role in defining centromere identity, structure, and function but is …

Meters of DNA wrap around histone proteins to form nucleosomes and fit inside the micron-
diameter nucleus. For the genetic information encoded in the DNA to become available for …

The centromere is essential for the segregation of chromosomes, as it serves as attachment
site for microtubules to mediate chromosome segregation during mitosis and meiosis. In …

Gene regulation programs establish cellular identity and rely on dynamic changes in the
structural packaging of genomic DNA. The DNA is packaged in chromatin, which is formed …

The centromere specific histone H3 variant CENP-A/CENH3 specifies where the
kinetochore is formed in most eukaryotes. Despite tight regulation of CENP-A levels in …

Holliday Junction Recognition Protein (HJURP) is a centromeric histone chaperone
involving in de novo histone H3 variant CenH3 (CENP-A) recruitment. Our transcriptome …

Centromeres are built on repetitive DNA sequences (CenDNA) and a specific chromatin
enriched with the histone H3 variant CENP‐A, the epigenetic mark that identifies centromere …