IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or
diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum …

Dendritic cells (DCs) are key regulators of immune responses that operate at the interface
between innate and adaptive immunity, and defects in DC functions contribute to the …

Current research efforts on neurological diseases are focused on identifying novel disease
biomarkers to aid in diagnosis, provide accurate prognostic information and monitor disease …

In chronic inflammatory diseases of the central nervous system (CNS), immune cells
persisting behind the blood-brain barrier are supposed to promulgate local tissue …

Despite major progress in the treatment of autoimmune diseases in the past two decades,
most therapies do not cure disease and can be associated with increased risk of infection …

Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most
prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein …

Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to
middle-aged adults, affecting~ 2.5 million people worldwide. Currently, most therapeutics for …