The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation,
transformation and death. Using mice and cells lacking AP-1 components, the target-genes …

A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …

The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to
be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has …

Brain ischemia and reperfusion engage multiple independently-fatal terminal pathways
involving loss of membrane integrity in partitioning ions, progressive proteolysis, and …

The c-Jun NH 2-terminal kinase (Jnk) family is implicated in apoptosis, but its function in
brain development is unclear. Here, we address this issue using mutant mice lacking …

Abstract c-Jun is a major component of the heterodimeric transcription factor AP-1 and is
essential for embryonic development, as fetuses lacking Jun die at mid-gestation 1, 2 with …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

The c-Jun NH2-terminal kinases (JNKs) phosphorylate and activate members of the
activator protein-1 (AP-1) transcription factor family and other cellular factors implicated in …

Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue
that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic …