RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …

RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …

Many biological processes are RNA-mediated, but higher-order structures for most RNAs
are unknown, which makes it difficult to understand how RNA structure governs function …

RNA has the intrinsic property to base pair, forming complex structures fundamental to its
diverse functions. Here, we develop PARIS, a method based on reversible psoralen …

A large portion of the human genome is transcribed into RNAs without known protein-coding
functions, far outnumbering coding transcription units. Extensive studies of long noncoding …

Only relatively recently has it become clear that mammalian genomes encode tens of
thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed …

Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemistries exploit
small electrophilic reagents that react with 2′-hydroxyl groups to interrogate RNA structure …

An emerging body of evidence indicates that post-transcriptional gene regulation relies not
only on the sequence of mRNAs but also on their folding into intricate secondary structures …

Long noncoding RNAs (lncRNAs) are sequences of 200 nucleotides or more that are
transcribed from a large portion of the mammalian genome. While hypothesized to have a …