Biological and physiological role of reactive oxygen species–the good, the bad and the ugly
Reactive oxygen species (ROS) are chemically reactive molecules that are naturally
produced within biological systems. Research has focused extensively on revealing the …
produced within biological systems. Research has focused extensively on revealing the …
A cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells
Nanoparticles that functionally mimic the activity of metal‐containing enzymes (metallo‐
nanozymes) are of therapeutic importance for treating various diseases. However, it is still …
nanozymes) are of therapeutic importance for treating various diseases. However, it is still …
Targeting of nuclear factor-κB and proteasome by dithiocarbamate complexes with metals
B Cvek, Z Dvorak - Current pharmaceutical design, 2007 - ingentaconnect.com
Dithiocarbamates and their complexes with transition metals have been used as common
pesticides, vulcanizing or analytical agents for decades. These compounds are one of the …
pesticides, vulcanizing or analytical agents for decades. These compounds are one of the …
Cerium vanadate nanozyme with pH-dependent dual enzymatic activity for glioblastoma targeted therapy and postradiotherapy damage protection
X Han, B Li, W Wang, B Feng, Q Tang, Y Qi, R Zhao… - ACS …, 2024 - ACS Publications
Nanocatalytic therapy is an emerging technology that uses synthetic nanoscale enzyme
mimics for biomedical treatment. However, in the field of neuroscience, achieving …
mimics for biomedical treatment. However, in the field of neuroscience, achieving …
A redox modulatory SOD mimetic nanozyme prevents the formation of cytotoxic peroxynitrite and improves nitric oxide bioavailability in human endothelial cells
M Geethika, N Singh, S Kumar… - Advanced …, 2023 - Wiley Online Library
The endothelium‐derived signalling molecule nitric oxide (NO) in addition to controlling
multifarious servo‐regulatory functions, suppresses key processes in vascular lesion …
multifarious servo‐regulatory functions, suppresses key processes in vascular lesion …
The specific inhibition of SOD1 selectively promotes apoptosis of cancer cells via regulation of the ROS signaling network
X Li, Y Chen, J Zhao, J Shi, M Wang… - Oxidative medicine …, 2019 - Wiley Online Library
Multiple signaling pathways including ERK, PI3K‐Akt, and NF‐κB, which are essential for
onset and development of cancer, can be activated by intracellularly sustained high levels of …
onset and development of cancer, can be activated by intracellularly sustained high levels of …
Potential therapeutic targets shared between leishmaniasis and cancer
S Rashidi, C Fernández-Rubio, R Manzano-Román… - Parasitology, 2021 - cambridge.org
The association of leishmaniasis and malignancies in human and animal models has been
highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer …
highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer …
Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism
Aims: Polyphenolic phytochemicals have anticancer properties. However, in mechanistic
studies, lack of correlation with the bioavailable concentrations is a critical issue. Some …
studies, lack of correlation with the bioavailable concentrations is a critical issue. Some …
Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive …
X Liu, Y Xu, S Chen, Z Tan, K **ong, Y Li, Y Ye… - Free Radical Biology …, 2014 - Elsevier
Cartilage repair by mesenchymal stem cells (MSCs) often occurs in diseased joints in which
the inflamed microenvironment impairs chondrogenic maturation and causes neocartilage …
the inflamed microenvironment impairs chondrogenic maturation and causes neocartilage …
SOD1 inhibition enhances sorafenib efficacy in HBV‐related hepatocellular carcinoma by modulating PI3K/Akt/mTOR pathway and ROS‐mediated cell death
J Lee, J Kim, R Lee, E Lee, HI An… - Journal of Cellular …, 2024 - Wiley Online Library
Abstract Hepatitis B Virus (HBV) infection significantly elevates the risk of hepatocellular
carcinoma (HCC), with the HBV X protein (HBx) playing a crucial role in cancer progression …
carcinoma (HCC), with the HBV X protein (HBx) playing a crucial role in cancer progression …