Biological and physiological role of reactive oxygen species–the good, the bad and the ugly

L Zuo, T Zhou, BK Pannell, AC Ziegler… - Acta …, 2015 - Wiley Online Library
Reactive oxygen species (ROS) are chemically reactive molecules that are naturally
produced within biological systems. Research has focused extensively on revealing the …

A cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells

N Singh, SK NaveenKumar… - Angewandte Chemie …, 2021 - Wiley Online Library
Nanoparticles that functionally mimic the activity of metal‐containing enzymes (metallo‐
nanozymes) are of therapeutic importance for treating various diseases. However, it is still …

Targeting of nuclear factor-κB and proteasome by dithiocarbamate complexes with metals

B Cvek, Z Dvorak - Current pharmaceutical design, 2007 - ingentaconnect.com
Dithiocarbamates and their complexes with transition metals have been used as common
pesticides, vulcanizing or analytical agents for decades. These compounds are one of the …

Cerium vanadate nanozyme with pH-dependent dual enzymatic activity for glioblastoma targeted therapy and postradiotherapy damage protection

X Han, B Li, W Wang, B Feng, Q Tang, Y Qi, R Zhao… - ACS …, 2024 - ACS Publications
Nanocatalytic therapy is an emerging technology that uses synthetic nanoscale enzyme
mimics for biomedical treatment. However, in the field of neuroscience, achieving …

A redox modulatory SOD mimetic nanozyme prevents the formation of cytotoxic peroxynitrite and improves nitric oxide bioavailability in human endothelial cells

M Geethika, N Singh, S Kumar… - Advanced …, 2023 - Wiley Online Library
The endothelium‐derived signalling molecule nitric oxide (NO) in addition to controlling
multifarious servo‐regulatory functions, suppresses key processes in vascular lesion …

The specific inhibition of SOD1 selectively promotes apoptosis of cancer cells via regulation of the ROS signaling network

X Li, Y Chen, J Zhao, J Shi, M Wang… - Oxidative medicine …, 2019 - Wiley Online Library
Multiple signaling pathways including ERK, PI3K‐Akt, and NF‐κB, which are essential for
onset and development of cancer, can be activated by intracellularly sustained high levels of …

Potential therapeutic targets shared between leishmaniasis and cancer

S Rashidi, C Fernández-Rubio, R Manzano-Román… - Parasitology, 2021 - cambridge.org
The association of leishmaniasis and malignancies in human and animal models has been
highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer …

Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism

M Benlloch, E Obrador, SL Valles… - Antioxidants & redox …, 2016 - liebertpub.com
Aims: Polyphenolic phytochemicals have anticancer properties. However, in mechanistic
studies, lack of correlation with the bioavailable concentrations is a critical issue. Some …

Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive …

X Liu, Y Xu, S Chen, Z Tan, K **ong, Y Li, Y Ye… - Free Radical Biology …, 2014 - Elsevier
Cartilage repair by mesenchymal stem cells (MSCs) often occurs in diseased joints in which
the inflamed microenvironment impairs chondrogenic maturation and causes neocartilage …

SOD1 inhibition enhances sorafenib efficacy in HBV‐related hepatocellular carcinoma by modulating PI3K/Akt/mTOR pathway and ROS‐mediated cell death

J Lee, J Kim, R Lee, E Lee, HI An… - Journal of Cellular …, 2024 - Wiley Online Library
Abstract Hepatitis B Virus (HBV) infection significantly elevates the risk of hepatocellular
carcinoma (HCC), with the HBV X protein (HBx) playing a crucial role in cancer progression …