The discovery that mammalian cells generate nitric oxide, a gas previously considered to be
merely an atmospheric pollutant, is providing important information about many biologic …

Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Expression of innate immune response proteins, including IL-1β, TNF, and the cytokine-
inducible isoform of nitric oxide synthase (iNOS), have been documented in the hearts of …

Over the past 5 years there has been an explosion of new information on the physiological
and pathophysiological roles of NO within the heart as in other organ systems. In this review …

BACKGROUND The endothelium synthesizes and releases a relaxing factor with the
physiochemical properties of nitric oxide (NO). However, the role of endothelium-derived NO …

CIIF= congestin• heart failure; eNOS= constitutive nitric oxide s\· nthesis; IL-l= interleukin-1;
IL-lra= interleukin-1 receptor antagonist; IL-6= interleukin-6; IL-8= interleukin-8; iNOS …

The endothelium is involved in the control of vascular tone and homeostasis. Risk factors for
arteriosclerosis, as well as other conditions have been shown to be associated with a …

Increased inducible nitric oxide synthase (iNOS) expression is a component of the immune
response and has been demonstrated in cardiomyocytes in septic shock, myocarditis …

Background There is increasing evidence that alterations in nitric oxide synthesis are of
pathophysiological importance in heart failure. A number of studies have shown altered …

BACKGROUND In isolated mammalian cardiomyocytes, papillary muscle preparations, and
ejecting hearts, nitric oxide (NO) or other cyclic GMP-elevating interventions increase …