Immunotherapy is an effective treatment option that revolutionizes the management of
various cancers. Nevertheless, only a subset of patients receiving immunotherapy exhibit …

Oxidative balance plays a pivotal role in physiological homeostasis, and many diseases,
particularly age-related conditions, are closely associated with oxidative imbalance. While …

Abstract Background Boolean Networks (BNs) are a popular dynamical model in biology
where the state of each component is represented by a variable taking binary values that …

CD8+ T lymphocytes are one of the main effector cells of the immune system, they protect
the organism against intracellular threats such as viruses and bacteria, as well as …

At the crossroad between biology and mathematical modeling, computational systems
biology can contribute to a mechanistic understanding of high-level biological phenomenon …

Neonates are highly susceptible to intracellular pathogens, leading to high morbidity and
mortality rates. CD8+ T lymphocytes are responsible for the elimination of infected cells …

Asynchronous Boolean networks are a type of discrete dynamical system in which each
variable can take one of two states, and a single variable state is updated in each time step …

The human microbiota plays a critical role in host health. Proper development of the infant
microbiome is particularly important. Its dysbiosis leads to both short-term health issues and …

The adaptive immune response is coordinated by CD4+ T cells, which determine the type
and strength of the immune response and the effector cells involved. It has been reported …

Neonatal life is marked by rapid antigen exposure, necessitating establishment of peripheral
immune tolerance via conversion of naïve CD4+ T cells into regulatory T cells (Tregs). Here …