Epithelia are robust tissues that support the structure of embryos and organs and serve as
effective barriers against pathogens. Epithelia also chemically separate different …

During development, mechanical forces cause changes in size, shape, number, position,
and gene expression of cells. They are therefore integral to any morphogenetic processes …

Two-photon fluorescence microscopy enables scientists in various fields including
neuroscience,, embryology and oncology to visualize in vivo and ex vivo tissue morphology …

Our knowledge of the principles by which organ architecture develops through complex
collective cell behaviours is still limited. Recent work has shown that the shape of such …

The interaction of cells within their microenvironmental niche is fundamental to cell
migration, positioning, growth and differentiation in order to form and maintain complex …

Embryo morphogenesis is impacted by dynamic changes in tissue material properties,
which have been proposed to occur via processes akin to phase transitions (PTs). Here, we …

Cancer cell invasion is an adaptive process based on cell-intrinsic properties to migrate
individually or collectively, and their adaptation to encountered tissue structure acting as …

The preparation, staining, visualization and interpretation of histological images of tissue is
well accepted as the gold standard process for the diagnosis of disease. These methods …

The comprehensive reconstruction of cell lineages in complex multicellular organisms is a
central goal of developmental biology. We present an open-source computational …

During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …