Parkinson's disease: etiology, neuropathology, and pathogenesis

A Kouli, KM Torsney, WL Kuan - Exon Publications, 2018 - exonpublications.com
Parkinson's disease (PD) is a common neurodegenerative disorder. While a number of
nonmotor manifestations arise, the typical clinical features involve a movement disorder …

Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

The role of microglia in retinal neurodegeneration: Alzheimer's disease, Parkinson, and glaucoma

AI Ramirez, R de Hoz, E Salobrar-Garcia… - Frontiers in aging …, 2017 - frontiersin.org
Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Visual dysfunction in Parkinson's disease

RS Weil, AE Schrag, JD Warren, SJ Crutch, AJ Lees… - Brain, 2016 - academic.oup.com
Patients with Parkinson's disease have a number of specific visual disturbances. These
include changes in colour vision and contrast sensitivity and difficulties with complex visual …

[HTML][HTML] Arizona study of aging and neurodegenerative disorders and brain and body donation program

TG Beach, CH Adler, LI Sue, G Serrano… - … : official journal of the …, 2015 - ncbi.nlm.nih.gov
Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …

Molecular pathological classification of neurodegenerative diseases: turning towards precision medicine

GG Kovacs - International journal of molecular sciences, 2016 - mdpi.com
Neurodegenerative diseases (NDDs) are characterized by selective dysfunction and loss of
neurons associated with pathologically altered proteins that deposit in the human brain but …

Molecular pathology of neurodegenerative diseases: principles and practice

GG Kovacs - Journal of clinical pathology, 2019 - jcp.bmj.com
Neurodegenerative diseases are characterised by selective dysfunction and progressive
loss of synapses and neurons associated with pathologically altered proteins that deposit …

Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough

U Ganguly, S Singh, S Pal, S Prasad… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

Past, present and future role of retinal imaging in neurodegenerative disease

AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

Neuropathological basis of nonmotor manifestations of Parkinson's disease

CH Adler, TG Beach - Movement Disorders, 2016 - Wiley Online Library
Nonmotor manifestations of Parkinson's disease (PD) can begin well before motor PD
begins. It is now clear, from clinical and autopsy studies, that there is significant Lewy‐type α …