Current achievements and applications of transcriptomics in personalized cancer medicine

S Supplitt, P Karpinski, M Sasiadek… - International Journal of …, 2021 - mdpi.com
Over the last decades, transcriptome profiling emerged as one of the most powerful
approaches in oncology, providing prognostic and predictive utility for cancer management …

TGR5, not only a metabolic regulator

C Guo, WD Chen, YD Wang - Frontiers in physiology, 2016 - frontiersin.org
G-protein-coupled bile acid receptor, Gpbar1 (TGR5), is a member of G-protein-coupled
receptor (GPCR) superfamily. High levels of TGR5 mRNA were detected in several tissues …

Spatial metabolomics identifies distinct tumor-specific subtypes in gastric cancer patients

J Wang, T Kunzke, VM Prade, J Shen, A Buck… - Clinical Cancer …, 2022 - AACR
Purpose: Current systems of gastric cancer molecular classification include genomic,
molecular, and morphological features. Gastric cancer classification based on tissue …

Identification of gastric cancer subtypes based on pathway clustering

L Li, X Wang - npj Precision Oncology, 2021 - nature.com
Gastric cancer (GC) is highly heterogeneous in the stromal and immune microenvironment,
genome instability (GI), and oncogenic signatures. However, a classification of GC by …

Chromosomal instability in gastric cancer: role in tumor development, progression, and therapy

MV Nemtsova, EB Kuznetsova, IV Bure - International Journal of …, 2023 - mdpi.com
According to the Cancer Genome Atlas (TCGA), gastric cancers are classified into four
molecular subtypes: Epstein–Barr virus-positive (EBV+), tumors with microsatellite instability …

[HTML][HTML] Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway

XR Zhang, SY Wang, W Sun… - Molecular medicine …, 2018 - spandidos-publications.com
Isoliquiritigenin (ISL) is a flavonoid extracted from licorice root, which is known to serve
important antitumor roles in numerous types of cancers; however, its effect on gastric cancer …

Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction …

T Yoshida, G Ogura, M Tanabe, T Hayashi… - Cancer biology & …, 2022 - Taylor & Francis
This real-world study examined the prevalence of programmed death ligand-1 (PD-L1)
expression and assessed the frequency of microsatellite instability-high (MSI-H) status and …

Predicting bipolar disorder and schizophrenia based on non-overlap** genetic phenotypes using deep neural network

S Karthik, M Sudha - Evolutionary Intelligence, 2021 - Springer
Computational Psychiatry is an emerging field of science. It focuses on identifying the
complex relationship between the brain's neurobiology. Mental illness has recently become …

Procyanidin B2 induces apoptosis and autophagy in gastric cancer cells by inhibiting Akt/mTOR signaling pathway

Y Li, X Lu, P Tian, K Wang, J Shi - BMC Complementary Medicine and …, 2021 - Springer
Abstract Background Procyanidin B2 (PB2), a unique component of the grape seed and
other medicinal plants. PB2 has shown wide anticancer activity in various human cancer …

The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway

Z Xu, J Feng, Y Li, D Guan, H Chen, X Zhai… - Chemico-Biological …, 2020 - Elsevier
Cancer metastasis and resistance for chemotherapeutic agent correlate with epithelial-
mesenchymal transition (EMT), while ROS production also involves in the EMT process …