Stiffness sensing by cells

PA Janmey, DA Fletcher… - Physiological …, 2020 - journals.physiology.org
Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Vimentin on the move: new developments in cell migration

RA Battaglia, S Delic, H Herrmann… - F1000Research, 2018 - pmc.ncbi.nlm.nih.gov
The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins,
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …

Direct evidence that tumor cells soften when navigating confined spaces

C Rianna, M Radmacher, S Kumar - Molecular biology of the cell, 2020 - molbiolcell.org
The mechanical properties of cells strongly regulate many physiological and pathological
processes. For example, in cancer, invasive and metastatic tumor cells have often been …

[HTML][HTML] Soft matter analysis via atomic force microscopy (AFM): A review

AM Joshua, G Cheng, EV Lau - Applied Surface Science Advances, 2023 - Elsevier
Soft materials or soft condensed matter are being globally developed for various
technological applications for chemical, consumer goods, pharmaceutical, agri-business …

Tumor cell nuclei soften during transendothelial migration

AB Roberts, J Zhang, VR Singh, M Nikolić… - Journal of …, 2021 - Elsevier
During cancer metastasis, tumor cells undergo significant deformation in order to traverse
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …

[HTML][HTML] Characterization of breast cancer aggressiveness by cell mechanics

B Zbiral, A Weber, MM Vivanco… - International Journal of …, 2023 - mdpi.com
In healthy tissues, cells are in mechanical homeostasis. During cancer progression, this
equilibrium is disrupted. Cancer cells alter their mechanical phenotype to a softer and more …

[HTML][HTML] Viscoelastic properties in cancer: From cells to spheroids

Y Abidine, A Giannetti, J Revilloud, VM Laurent… - Cells, 2021 - mdpi.com
AFM-based rheology methods enable the investigation of the viscoelastic properties of
cancer cells. Such properties are known to be essential for cell functions, especially for …

Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion

M Sarna, M Krzykawska-Serda, M Jakubowska… - Scientific reports, 2019 - nature.com
Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs.
Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts …

Recent advances in AFM-based biological characterization and applications at multiple levels

W Liang, H Shi, X Yang, J Wang, W Yang, H Zhang… - Soft Matter, 2020 - pubs.rsc.org
Atomic force microscopy (AFM) has found a wide range of bio-applications in the past few
decades due to its ability to measure biological samples in natural environments at a high …

Using adhesive micropatterns and AFM to assess cancer cell morphology and mechanics

M Liboz, A Allard, M Malo, G Lamour… - … Applied Materials & …, 2023 - ACS Publications
The mechanical properties of living cells reflect their physiological and pathological state. In
particular, cancer cells undergo cytoskeletal modifications that typically make them softer …