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Stiffness sensing by cells
Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …
signals are important elements in normal tissue development as well as in disease initiation …
Vimentin on the move: new developments in cell migration
The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins,
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …
Direct evidence that tumor cells soften when navigating confined spaces
The mechanical properties of cells strongly regulate many physiological and pathological
processes. For example, in cancer, invasive and metastatic tumor cells have often been …
processes. For example, in cancer, invasive and metastatic tumor cells have often been …
[HTML][HTML] Soft matter analysis via atomic force microscopy (AFM): A review
Soft materials or soft condensed matter are being globally developed for various
technological applications for chemical, consumer goods, pharmaceutical, agri-business …
technological applications for chemical, consumer goods, pharmaceutical, agri-business …
Tumor cell nuclei soften during transendothelial migration
During cancer metastasis, tumor cells undergo significant deformation in order to traverse
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …
[HTML][HTML] Characterization of breast cancer aggressiveness by cell mechanics
In healthy tissues, cells are in mechanical homeostasis. During cancer progression, this
equilibrium is disrupted. Cancer cells alter their mechanical phenotype to a softer and more …
equilibrium is disrupted. Cancer cells alter their mechanical phenotype to a softer and more …
[HTML][HTML] Viscoelastic properties in cancer: From cells to spheroids
Y Abidine, A Giannetti, J Revilloud, VM Laurent… - Cells, 2021 - mdpi.com
AFM-based rheology methods enable the investigation of the viscoelastic properties of
cancer cells. Such properties are known to be essential for cell functions, especially for …
cancer cells. Such properties are known to be essential for cell functions, especially for …
Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs.
Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts …
Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts …
Recent advances in AFM-based biological characterization and applications at multiple levels
Atomic force microscopy (AFM) has found a wide range of bio-applications in the past few
decades due to its ability to measure biological samples in natural environments at a high …
decades due to its ability to measure biological samples in natural environments at a high …
Using adhesive micropatterns and AFM to assess cancer cell morphology and mechanics
The mechanical properties of living cells reflect their physiological and pathological state. In
particular, cancer cells undergo cytoskeletal modifications that typically make them softer …
particular, cancer cells undergo cytoskeletal modifications that typically make them softer …