mRNA stability influences gene expression and translation in almost all living organisms,
and the levels of mRNA molecules in the cell are determined by a balance between …

Epithelial-mesenchymal transition (EMT) is a major contributor to metastatic progression and
is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are …

Small bowel vascular malformation disease (SBVM) commonly causes obscure
gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of …

Although mammals possess roughly the same number of protein-coding genes as worms, it
is evident that the non-coding transcriptome content has become far broader and more …

The long non-coding RNA EPR is expressed in epithelial tissues, binds to chromatin and
controls distinct biological activities in mouse mammary gland cells. Because of its high …

Significance: Adaptor proteins control the spatiotemporal dynamics of cellular signaling.
Dysregulation of adaptor protein function can cause aberrant cell signaling and promote …

EPR is a long non-coding RNA (lncRNA) that controls cell proliferation in mammary gland
cells by regulating gene transcription. Here, we report on Mettl7a1 as a direct target of EPR …

The α-arrestin ARRDC3 is a recently discovered tumor suppressor in invasive breast cancer
that functions as a multifaceted adaptor protein to control protein trafficking and cellular …

Cholangiocarcinoma is a devastating liver cancer characterized by high aggressiveness
and therapy resistance, resulting in poor prognosis. Long non-coding RNAs and signals …

The ubiquitin-proteasome system maintains protein homoeostasis, underpins the cell cycle,
and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which …