Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
Autophagy in the liver: functions in health and disease
T Ueno, M Komatsu - Nature reviews Gastroenterology & hepatology, 2017 - nature.com
The concept of macroautophagy was established in 1963, soon after the discovery of
lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced …
lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced …
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …
apical activator of the DNA damage response in the face of DNA double-strand breaks …
ATM functions at the peroxisome to induce pexophagy in response to ROS
Peroxisomes are highly metabolic, autonomously replicating organelles that generate
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …
Mechanisms of ATM activation
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
Peroxisomes take shape
Peroxisomes carry out various oxidative reactions that are tightly regulated to adapt to the
changing needs of the cell and varying external environments. Accordingly, they are …
changing needs of the cell and varying external environments. Accordingly, they are …
ATM activation by oxidative stress
The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …
Ataxia‐telangiectasia: A review of clinical features and molecular pathology
Abstract Ataxia‐telangiectasia (A‐T) is an autosomal recessive primary immunodeficiency
(PID) disease that is caused by mutations in ataxia‐telangiectasia mutated (ATM) gene …
(PID) disease that is caused by mutations in ataxia‐telangiectasia mutated (ATM) gene …
Regulation of catalase expression in healthy and cancerous cells
Catalase is an important antioxidant enzyme that dismutates hydrogen peroxide into water
and molecular oxygen. The catalase gene has all the characteristics of a housekee** …
and molecular oxygen. The catalase gene has all the characteristics of a housekee** …
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
First described over 80 years ago, ataxia-telangiectasia (AT) was defined as a clinical entity
50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer …
50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer …