Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH)
releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and …

Small synthetic molecules called growth hormone secretagogues (GHSs) stimulate the
release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein …

Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …

Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities.
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …

The gastrointestinal microbiota is emerging as a unique and inexhaustible source for
metabolites with potential to modulate G-protein coupled receptors (GPCRs). The ghrelin …

Background—Ghrelin is a novel growth hormone-releasing peptide that has been shown to
improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and …

Recent progress in the field of energy homeostasis was triggered by the discovery of
adipocyte hormone leptin and revealed a complex regulatory neuroendocrine network. A …

Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth
hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n …

Many peptides are synthesized and released from the gastrointestinal tract. Although their
roles in the regulation of gastrointestinal function have been known for some time, it is now …