To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal
naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic …

Despite the development of second-generation antiandrogens, acquired resistance to
hormone therapy remains a major challenge in treating advanced prostate cancer. We find …

Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the
accumulation of senescent cells is thought to drive age-related pathology through a …

In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …

DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …

Sepsis is an often deadly complication of infection in which systemic inflammation damages
the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the …

Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell
resource, with potential for studying disease and use in regenerative medicine. However …

Acridine Orange is a cell-permeable green fluorophore that can be protonated and trapped
in acidic vesicular organelles (AVOs). Its metachromatic shift to red fluorescence is …

Fibroblasts are primary cellular protagonists of wound healing. They also exhibit circadian
timekee**, which imparts an approximately 24-hour rhythm to their biological function. We …