Current efforts in precision oncology largely focus on the benefit of genomics-guided
therapy. Yet, advances in sequencing techniques provide an unprecedented view of the …

Understanding the profile of oncogene and tumor suppressor gene mutations with their
interactions and impact on the prognosis of multiple myeloma (MM) can improve the …

Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote
treatment resistance,,–. This phenomenon has been implicated in chemorefractory small cell …

Tumor genoty** is not routinely performed in localized non–small cell lung cancer
(NSCLC) due to lack of associations of mutations with outcome. Here, we analyze 232 …

Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can
be exploited as drug targets when translatable to patients. The Cancer Genome Atlas …

Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a
frequent event in human malignancies, yet the underlying molecular mechanisms are still …

Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive
research. Here, we review the current understanding of the functions of the nuclear factor …

Alternative splicing of mRNA precursors represents a key gene expression regulatory step
and permits the generation of distinct protein products with diverse functions. In a genome …