DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …

Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like
nanoparticles to enhance B-cell activation. However, the effects of antigen copy number …

Unlike proteins, which have a wealth of validated structural data, experimentally or
computationally validated DNA origami datasets are limited. Here we present a graph neural …

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize
antigens and enhance humoral immunity through multivalent antigen display. However, P …

Wireframe DNA origami assemblies can now be programmed automatically from the top-
down using simple wireframe target geometries, or meshes, in 2D and 3D, using either rigid …

T-cells detect with their T-cell antigen receptors (TCRs) the presence of rare agonist
peptide/MHC complexes (pMHCs) on the surface of antigen presenting cells (APCs). How …

DNA nanostructures are a promising tool to deliver molecular payloads to cells. DNA
origami structures, where long single-stranded DNA is folded into a compact nanostructure …

Hybrid RNA: DNA origami, in which a long RNA scaffold strand folds into a target
nanostructure via thermal annealing with complementary DNA oligos, has only been …

Control over the copy number and nanoscale positioning of quantum dots (QDs) is critical to
their application to functional nanomaterials design. However, the multiple non-specific …