Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
An overview of vaccine adjuvants: current evidence and future perspectives
Vaccinations are one of the most important preventive tools against infectious diseases.
Over time, many different types of vaccines have been developed concerning the antigen …
Over time, many different types of vaccines have been developed concerning the antigen …
[HTML][HTML] Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled …
Background Stalled progress in controlling Plasmodium falciparum malaria highlights the
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …
RTS, S/AS01 vaccine (Mosquirix™): an overview
MB Laurens - Human vaccines & immunotherapeutics, 2020 - Taylor & Francis
Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …
Malaria vaccines: recent advances and new horizons
The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver
Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial
M Oneko, LC Steinhardt, R Yego, RE Wiegand… - Nature Medicine, 2021 - nature.com
The radiation-attenuated Plasmodium falciparum sporozoite (PfSPZ) vaccine provides
protection against P. falciparum infection in malaria-naïve adults. Preclinical studies show …
protection against P. falciparum infection in malaria-naïve adults. Preclinical studies show …
Cytokines and chemokines in cerebral malaria pathogenesis
Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …
[HTML][HTML] Antibody feedback limits the expansion of B cell responses to malaria vaccination but drives diversification of the humoral response
Generating sufficient antibody to block infection is a key challenge for vaccines against
malaria. Here, we show that antibody titers to a key target, the repeat region of the …
malaria. Here, we show that antibody titers to a key target, the repeat region of the …