Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …

In amniotes, the development of the primitive streak and its accompanying 'organizer'define
the first stages of gastrulation. Although these structures have been characterized in detail in …

The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the
three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo …

The differentiation of pluripotent stem cells to hepatocytes is well established, yet current
methods suffer from several drawbacks. These include a lack of definition and …

Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid
homeostasis and normalizing leukocyte transmigration. However, the mechanisms of …

Faithful execution of developmental programs relies on the acquisition of unique cell
identities from pluripotent progenitors, a process governed by combinatorial inputs from …

TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

Purpose This study aimed to uncover novel cell types in heterogenous basal limbus of
human cornea for identifying LSC at single cell resolution. Methods Single cells of human …