The initial management of the multiple trauma victim requires evaluation for potential
hemorrhage and ongoing monitoring to assess the efficacy of resuscitation and avoid …

Severely injured trauma victims are at high risk of development of the multiple organ
dysfunction syndrome (MODS) or death. To maximize chances for survival, treatment …

Clinicians now realize the limitations of the physical examination in detecting compensated
shock states, the severity of uncompensated states, and in determining the adequacy of …

Background: Despite normalization of vital signs, critically injured patients may remain in a
state of occult underresuscitation that sets the stage for sepsis, organ failure, and death. A …

Tissue oxygen tension is the partial pressure of oxygen within the interstitial space of an
organ bed. As it represents the balance between local oxygen delivery and consumption at …

Maintenance or prompt restoration of an oxygen supply sufficient to facilitate adequate
cellular metabolism is fundamental in maintaining organ function. This is particularly …

The determination of reliable biomarkers capable to predict clinical outcome of a trauma
patient remains essential toward better therapeutic management of the patient in the …

Background The ideal resuscitation fluid for the trauma patient would be readily available to
prehospital personnel, universally compatible, effective when given in small volumes, and …

Abstract In 1998, Baxter Healthcare announced that it was abandoning its product, diaspirin–
crosslinked hemoglobin (DCLHb), the first 'blood substitute'to complete all phases of human …

Alterations in oxygen transport and use are integral to the development of multiple organ
failure; therefore, the ultimate goal of resuscitation is to restore effective tissue oxygenation …