Biological roles of adenine methylation in RNA

K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

The roles and implications of RNA m6A modification in cancer

X Deng, Y Qing, D Horne, H Huang… - Nature Reviews Clinical …, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q **ong, Z **… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

Molecular mechanisms of environmental exposures and human disease

H Wu, CM Eckhardt, AA Baccarelli - Nature reviews genetics, 2023 - nature.com
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

m6A RNA methylation: from mechanisms to therapeutic potential

PC He, C He - The EMBO journal, 2021 - embopress.org
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …

[HTML][HTML] METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer

H Chen, Y Pan, Q Zhou, C Liang, CC Wong, Y Zhou… - Gastroenterology, 2022 - Elsevier
Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …

Targeting the RNA m6A modification for cancer immunotherapy

X Li, S Ma, Y Deng, P Yi, J Yu - Molecular cancer, 2022 - Springer
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …

m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer

H Huang, H Weng, J Chen - Cancer cell, 2020 - cell.com
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

H Yin, X Zhang, P Yang, X Zhang, Y Peng, D Li… - Nature …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown
to play important roles in various biological processes. However, the roles of m6A …