Background The role of adjuvant chemotherapy for patients with rectal cancer after
preoperative (chemo) radiotherapy and surgery is uncertain. We did a meta-analysis of …

Due to differences in anatomy, primary rectal and colon cancer require different staging
procedures, different neo-adjuvant treatment and different surgical approaches. For …

PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is
not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally …

PURPOSE Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal
scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be …

The incidence of rectal cancer in the European Union is∼ 125 000 per year, ie∼ 35% of the
total colorectal cancer incidence, reflecting 15–25 cases/100 000 population per year and is …

Background Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery,
and adjuvant chemotherapy controls local disease, but distant metastases remain common …

Background Preoperative chemoradiotherapy with infusional fluorouracil, total mesorectal
excision surgery, and postoperative chemotherapy with fluorouracil was established by the …

Background The primary results of our phase II randomized trial suggested that compared
with conventional preoperative chemoradiation (CRT), the addition of chemotherapy (CT) …

The results of the PROCTOR-SCRIPT trial could not demonstrate a significant benefit of
adjuvant chemotherapy with fluoropyrimidine monotherapy regarding overall survival …

Background The role of adjuvant chemotherapy for patients with rectal cancer is
controversial, especially when used after preoperative chemoradiotherapy. Fluoropyrimidine …