The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

Over the past decade, compelling evidence has unveiled previously overlooked adaptive
characteristics of innate immune cells. Beyond their traditional role in providing short, non …

Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory
immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1 …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …