[HTML][HTML] NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis

S Nersesian, SL Schwartz, SR Grantham… - Translational …, 2021 - Elsevier
The immune landscape of a tumor is highly connected to patient prognosis and response to
treatment, but little is known about how natural killer (NK) cells predict overall survival (OS) …

NK cell-based immunotherapies in cancer

MH Shin, J Kim, SA Lim, J Kim, SJ Kim… - Immune network, 2020 - pmc.ncbi.nlm.nih.gov
With the development of technologies that can transform immune cells into therapeutic
modalities, immunotherapy has remarkably changed the current paradigm of cancer …

Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

R Hosseini, H Sarvnaz, M Arabpour, SM Ramshe… - Molecular Cancer, 2022 - Springer
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …

The extensive polymorphism of KIR genes

D Middleton, F Gonzelez - Immunology, 2010 - Wiley Online Library
The functions of human natural killer (NK) cells are controlled by diverse families of antigen
receptors. Prominent among these are the killer cell immunoglobulin‐like receptors (KIR), a …

An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression

YJ Kang, IC Jeung, A Park, YJ Park, H Jung… - Human …, 2014 - academic.oup.com
STUDY QUESTION Is the decreased natural killer (NK) cell cytolytic activity in the peritoneal
fluid (PF) of endometriosis patients due to primary cytokine activity? SUMMARY ANSWER …

TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals

F Wang, H Hou, S Wu, Q Tang, W Liu… - European journal of …, 2015 - Wiley Online Library
Human NK cells display extensive phenotypic and functional heterogeneity among healthy
individuals, but the mechanism responsible for this variation is still largely unknown. Here …

Cytokine-induced memory-like natural killer cells for cancer immunotherapy

M Tarannum, R Romee - Stem Cell Research & Therapy, 2021 - Springer
Natural killer cells are an important part of the innate immune system mediating robust
responses to virus-infected and malignant cells without needing prior antigen priming. NK …

The role of natural killer cells in Parkinson's disease

RH Earls, JK Lee - Experimental & Molecular Medicine, 2020 - nature.com
Numerous lines of evidence indicate an association between sustained inflammation and
Parkinson's disease, but whether increased inflammation is a cause or consequence of …

New players in immunity to tuberculosis: the host microbiome, lung epithelium, and innate immune cells

N Gupta, R Kumar, B Agrawal - Frontiers in immunology, 2018 - frontiersin.org
Tuberculosis (TB) is a highly contagious infection and devastating chronic disease, causing
10.4 million new infections and 1.8 million deaths every year globally. Efforts to control and …

Targeted therapies for pancreatic cancer: overview of current treatments and new opportunities for personalized oncology

C Leroux, G Konstantinidou - Cancers, 2021 - mdpi.com
Simple Summary The lack of early diagnosis and the absence of suitable biomarkers
coupled with resistance to available therapeutic options render pancreatic cancer one of the …