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Preoperative and postoperative systemic therapy for operable non–small-cell lung cancer
Cisplatin-based adjuvant chemotherapy remains the standard of care for patients with
resected stage II or III non–small-cell lung cancer. However, biomarker-informed clinical …
resected stage II or III non–small-cell lung cancer. However, biomarker-informed clinical …
Hyperprogressive disease: recognizing a novel pattern to improve patient management
Abstract Anti-PD-1/PD-L1 monoclonal antibodies have substantially improved the overall
survival of a subset of patients across multiple solid tumour types, but other patients can …
survival of a subset of patients across multiple solid tumour types, but other patients can …
Vorasidenib in IDH1-or IDH2-mutant low-grade glioma
IK Mellinghoff, MJ Van Den Bent… - … England Journal of …, 2023 - Mass Medical Soc
Background Isocitrate dehydrogenase (IDH)–mutant grade 2 gliomas are malignant brain
tumors that cause considerable disability and premature death. Vorasidenib, an oral brain …
tumors that cause considerable disability and premature death. Vorasidenib, an oral brain …
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
Pembrolizumab or placebo plus etoposide and platinum as first-line therapy for extensive-stage small-cell lung cancer: randomized, double-blind, phase III KEYNOTE …
PURPOSE Pembrolizumab monotherapy has shown antitumor activity in patients with small-
cell lung cancer (SCLC). The randomized, double-blind, phase III KEYNOTE-604 study …
cell lung cancer (SCLC). The randomized, double-blind, phase III KEYNOTE-604 study …
Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo …
J Rech, K Tascilar, M Hagen, A Kleyer, B Manger… - The Lancet, 2024 - thelancet.com
Background Individuals with anti-citrullinated protein antibodies (ACPAs) and subclinical
inflammatory changes in joints are at high risk of develo** rheumatoid arthritis. Treatment …
inflammatory changes in joints are at high risk of develo** rheumatoid arthritis. Treatment …
Association of measurable residual disease with survival outcomes in patients with acute myeloid leukemia: a systematic review and meta-analysis
Importance Measurable residual disease (MRD) refers to neoplastic cells that cannot be
detected by standard cytomorphologic analysis. In patients with acute myeloid leukemia …
detected by standard cytomorphologic analysis. In patients with acute myeloid leukemia …
Direct oral anticoagulants vs low-molecular-weight heparin and recurrent VTE in patients with cancer: a randomized clinical trial
Importance In patients with cancer who have venous thromboembolism (VTE) events, long-
term anticoagulation with low-molecular-weight heparin (LMWH) is recommended to prevent …
term anticoagulation with low-molecular-weight heparin (LMWH) is recommended to prevent …
Mechanical or biologic prostheses for aortic-valve and mitral-valve replacement
Background In patients undergoing aortic-valve or mitral-valve replacement, either a
mechanical or biologic prosthesis is used. Biologic prostheses have been increasingly …
mechanical or biologic prosthesis is used. Biologic prostheses have been increasingly …
[PDF][PDF] The recombinant shingles vaccine is associated with lower risk of dementia
There is emerging evidence that the live herpes zoster (shingles) vaccine might protect
against dementia. However, the existing data are limited and refer only to the live vaccine …
against dementia. However, the existing data are limited and refer only to the live vaccine …