Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

The DNA-damage response (DDR) arrests cell-cycle progression until damage is removed.
DNA-damage-induced cellular senescence is associated with persistent DDR. The …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-
protein complex'shelterin', thus protecting chromosome ends from DNA repair mechanisms …

Increasing evidence indicates that chromatin modifications are important regulators of
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …

Human telomere maintenance is essential for the protection of chromosome ends, and
changes in telomere length have been implicated in ageing and cancer,,,. Human telomere …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Human telomere length is controlled by a negative feedback loop based on the binding of
TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …