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RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
Unlocking G-quadruplexes as antiviral targets
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
Targeting RNA G‐quadruplex in SARS‐CoV‐2: A promising therapeutic target for COVID‐19?
C Zhao, G Qin, J Niu, Z Wang, C Wang… - Angewandte …, 2021 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 has become a global threat.
Understanding the underlying mechanisms and develo** innovative treatments are …
Understanding the underlying mechanisms and develo** innovative treatments are …
SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction
M Lavigne, O Helynck, P Rigolet… - Nucleic acids …, 2021 - academic.oup.com
The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by
coronavirus (CoV) genomes and several regions of this protein are essential for viral …
coronavirus (CoV) genomes and several regions of this protein are essential for viral …
Molecular basis of SARS-CoV-2 infection and rational design of potential antiviral agents: modeling and simulation approaches
The emergence in late 2019 of the coronavirus SARS-CoV-2 has resulted in the
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …
Structure and dynamics of RNA guanine quadruplexes in SARS-CoV-2 genome. Original strategies against emerging viruses
Guanine quadruplex (G4) structures in the viral genome have a key role in modulating
viruses' biological activity. While several DNA G4 structures have been experimentally …
viruses' biological activity. While several DNA G4 structures have been experimentally …
CNBP binds and unfolds in vitro G-quadruplexes formed in the SARS-CoV-2 positive and negative genome strands
The Coronavirus Disease 2019 (COVID-19) pandemic has become a global health
emergency with no effective medical treatment and with incipient vaccines. It is caused by a …
emergency with no effective medical treatment and with incipient vaccines. It is caused by a …
Thermodynamics of the interaction between the spike protein of severe acute respiratory syndrome coronavirus-2 and the receptor of human angiotensin-converting …
Since the end of 2019, the coronavirus SARS-CoV-2 has caused more than 1000000 deaths
all over the world and still lacks a medical treatment despite the attention of the whole …
all over the world and still lacks a medical treatment despite the attention of the whole …
Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A review
The coronavirus SARS-CoV-2 has caused a health care crisis all over the world since the
end of 2019. Although vaccines and neutralizing antibodies have been developed, rapidly …
end of 2019. Although vaccines and neutralizing antibodies have been developed, rapidly …
Resolving a guanine-quadruplex structure in the SARS-CoV-2 genome through circular dichroism and multiscale molecular modeling
The genome of SARS-CoV-2 coronavirus is made up of a single-stranded RNA fragment
that can assume a specific secondary structure, whose stability can influence the virus's …
that can assume a specific secondary structure, whose stability can influence the virus's …