RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Unlocking G-quadruplexes as antiviral targets

A Abiri, M Lavigne, M Rezaei, S Nikzad, P Zare… - Pharmacological …, 2021 - Elsevier
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …

Targeting RNA G‐quadruplex in SARS‐CoV‐2: A promising therapeutic target for COVID‐19?

C Zhao, G Qin, J Niu, Z Wang, C Wang… - Angewandte …, 2021 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 has become a global threat.
Understanding the underlying mechanisms and develo** innovative treatments are …

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

M Lavigne, O Helynck, P Rigolet… - Nucleic acids …, 2021 - academic.oup.com
The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by
coronavirus (CoV) genomes and several regions of this protein are essential for viral …

Molecular basis of SARS-CoV-2 infection and rational design of potential antiviral agents: modeling and simulation approaches

A Frances-Monerris, C Hognon, T Miclot… - Journal of Proteome …, 2020 - ACS Publications
The emergence in late 2019 of the coronavirus SARS-CoV-2 has resulted in the
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …

Structure and dynamics of RNA guanine quadruplexes in SARS-CoV-2 genome. Original strategies against emerging viruses

T Miclot, C Hognon, E Bignon, A Terenzi… - The Journal of …, 2021 - ACS Publications
Guanine quadruplex (G4) structures in the viral genome have a key role in modulating
viruses' biological activity. While several DNA G4 structures have been experimentally …

CNBP binds and unfolds in vitro G-quadruplexes formed in the SARS-CoV-2 positive and negative genome strands

G Bezzi, EJ Piga, A Binolfi, P Armas - International journal of molecular …, 2021 - mdpi.com
The Coronavirus Disease 2019 (COVID-19) pandemic has become a global health
emergency with no effective medical treatment and with incipient vaccines. It is caused by a …

Thermodynamics of the interaction between the spike protein of severe acute respiratory syndrome coronavirus-2 and the receptor of human angiotensin-converting …

C García-Iriepa, C Hognon… - The Journal of …, 2020 - ACS Publications
Since the end of 2019, the coronavirus SARS-CoV-2 has caused more than 1000000 deaths
all over the world and still lacks a medical treatment despite the attention of the whole …

Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A review

LY Zhai, AM Su, JF Liu, JJ Zhao, XG **… - International journal of …, 2022 - Elsevier
The coronavirus SARS-CoV-2 has caused a health care crisis all over the world since the
end of 2019. Although vaccines and neutralizing antibodies have been developed, rapidly …

Resolving a guanine-quadruplex structure in the SARS-CoV-2 genome through circular dichroism and multiscale molecular modeling

L d'Anna, T Miclot, E Bignon, U Perricone… - Chemical …, 2023 - pubs.rsc.org
The genome of SARS-CoV-2 coronavirus is made up of a single-stranded RNA fragment
that can assume a specific secondary structure, whose stability can influence the virus's …