The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …

To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …

Phages and plasmids are regarded as distinct types of mobile genetic elements that drive
bacterial evolution by horizontal gene transfer. However, the distinction between both types …

Viruses are integral components of all ecosystems and microbiomes on Earth. Through
pervasive infections of their cellular hosts, viruses can reshape microbial community …

In the twenty first century, the changing epidemiology of inflammatory bowel disease (IBD)
globally with increasing disease incidence across many countries relates to the altered gut …

Ecosystems are controlled by 'bottom-up'(resources) and 'top-down'(predation) forces. Viral
infection is now recognized as a ubiquitous top-down control of microbial growth across …

Gut bacteriome dysbiosis is known to be implicated in the pathogenesis of inflammatory
bowel disease (IBD). Crohn's disease (CD) is an IBD subtype with extensive mucosal …

The human body is host to large numbers of bacteriophages (phages)–a diverse group of
bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that …

Hundreds of trillions of diverse bacteriophages (phages) peacefully thrive within and on the
human body. However, whether and how phages influence their mammalian hosts is poorly …

Objective The pathogenesis of UC relates to gut microbiota dysbiosis. We postulate that
alterations in the viral community populating the intestinal mucosa play an important role in …