Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

Deterministic lateral displacement: Challenges and perspectives

A Hochstetter, R Vernekar, RH Austin, H Becker… - ACS …, 2020 - ACS Publications
The advent of microfluidics in the 1990s promised a revolution in multiple industries from
healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous …

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

BH Wunsch, JT Smith, SM Gifford, C Wang… - Nature …, 2016 - nature.com
Deterministic lateral displacement (DLD) pillar arrays are an efficient technology to sort,
separate and enrich micrometre-scale particles, which include parasites, bacteria, blood …

A review of sorting, separation and isolation of cells and microbeads for biomedical applications: microfluidic approaches

A Dalili, E Samiei, M Hoorfar - Analyst, 2019 - pubs.rsc.org
Several biomedical analyses are performed on particular types of cells present in body
samples or using functionalized microparticles. Success in such analyses depends on the …

Modular microfluidics for life sciences

J Wu, H Fang, J Zhang, S Yan - Journal of Nanobiotechnology, 2023 - Springer
The advancement of microfluidics has enabled numerous discoveries and technologies in
life sciences. However, due to the lack of industry standards and configurability, the design …

Microfluidic, marker-free isolation of circulating tumor cells from blood samples

NM Karabacak, PS Spuhler, F Fachin, EJ Lim, V Pai… - Nature protocols, 2014 - nature.com
The ability to isolate and analyze rare circulating tumor cells (CTCs) has the potential to
further our understanding of cancer metastasis and enhance the care of cancer patients. In …

Particle separation and sorting in microfluidic devices: a review

P Sajeesh, AK Sen - Microfluidics and nanofluidics, 2014 - Springer
Separation and sorting of micron-sized particles has great importance in diagnostics,
chemical and biological analyses, food and chemical processing and environmental …

Inertial focusing in microfluidics

JM Martel, M Toner - Annual review of biomedical engineering, 2014 - annualreviews.org
When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating
at an annulus in the pipe, scientists were perplexed and spent decades learning why such …

Label-free isolation of exosomes using microfluidic technologies

S Hassanpour Tamrin, A Sanati Nezhad, A Sen - ACS nano, 2021 - ACS Publications
Exosomes are cell-derived structures packaged with lipids, proteins, and nucleic acids. They
exist in diverse bodily fluids and are involved in physiological and pathological processes …

Microfluidic-based technologies for CTC isolation: a review of 10 years of intense efforts towards liquid biopsy

L Descamps, D Le Roy, AL Deman - International Journal of Molecular …, 2022 - mdpi.com
The selection of circulating tumor cells (CTCs) directly from blood as a real-time liquid
biopsy has received increasing attention over the past ten years, and further analysis of …