Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications

LA Milton, MS Viglione, LJY Ong, GP Nordin, YC Toh - Lab on a Chip, 2023 - pubs.rsc.org
Organs-on-a-chip, or OoCs, are microfluidic tissue culture devices with micro-scaled
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …

Microfluidic organ‐on‐a‐chip technology for advancement of drug development and toxicology

JD Caplin, NG Granados, MR James… - Advanced …, 2015 - Wiley Online Library
In recent years, the exploitation of phenomena surrounding microfluidics has seen an
increase in popularity, as researchers have found a way to use their unique properties to …

Development of a functional airway-on-a-chip by 3D cell printing

JY Park, H Ryu, B Lee, DH Ha, M Ahn, S Kim… - …, 2018 - iopscience.iop.org
We used 3D cell printing to emulate an airway coupled with a naturally-derived blood vessel
network in vitro. Decellularized extracellular matrix bioink derived from porcine tracheal …

A biomimetic multicellular model of the airways using primary human cells

KL Sellgren, EJ Butala, BP Gilmour, SH Randell… - Lab on a Chip, 2014 - pubs.rsc.org
Microfluidic cell cultures enable investigation of complex physiological tissue properties and
functionalities. For convenience, they are often implemented with immortalized cell lines, but …

[HTML][HTML] Alternative lung cell model systems for toxicology testing strategies: current knowledge and future outlook

JA Moura, K Meldrum, SH Doak, MJD Clift - Seminars in Cell & …, 2023 - Elsevier
Due to the current relevance of pulmonary toxicology (with focus upon air pollution and the
inhalation of hazardous materials), it is important to further develop and implement …

[HTML][HTML] Oral mucosa-on-a-chip to assess layer-specific responses to bacteria and dental materials

C Rahimi, B Rahimi, D Padova, SA Rooholghodos… - …, 2018 - pubs.aip.org
The human oral mucosa hosts a diverse microbiome and is exposed to potentially toxic
biomaterials from dental restoratives. Mucosal health is partly determined by cell and tissue …

Biomimetic microfluidic chips for toxicity assessment of environmental pollutants

X Du, J Yang - Science of The Total Environment, 2024 - Elsevier
Various types of pollutants widely present in environmental media, including synthetic and
natural chemicals, physical pollutants such as radioactive substances, ultraviolet rays, and …

Concise review: stem cell microenvironment on a chip: current technologies for tissue engineering and stem cell biology

DY Park, J Lim, JY Park, SH Lee - Stem cells translational …, 2015 - academic.oup.com
Stem cells have huge potential in many therapeutic areas. With conventional cell culture
methods, however, it is difficult to achieve in vivo-like microenvironments in which a number …

Temporal monitoring of differentiated human airway epithelial cells using microfluidics

C Blume, R Reale, M Held, TM Millar, JE Collins… - PloS one, 2015 - journals.plos.org
The airway epithelium is exposed to a variety of harmful agents during breathing and
appropriate cellular responses are essential to maintain tissue homeostasis. Recent …

[HTML][HTML] Biomimetics of the pulmonary environment in vitro: A microfluidics perspective

J Tenenbaum-Katan, A Artzy-Schnirman, R Fishler… - …, 2018 - pubs.aip.org
The entire luminal surface of the lungs is populated with a complex yet confluent,
uninterrupted airway epithelium in conjunction with an extracellular liquid lining layer that …