Fluorophores and probes are invaluable for the visualization of the location and dynamics of
gene expression, protein expression, and molecular interactions in complex living systems …

Trimethyl lock (TML) systems are based on ortho‐hydroxydihydrocinnamic acid derivatives
displaying increased lactonization reactivity owing to unfavorable steric interactions of three …

Abstract Human NAD (P) H: Quinone Oxidoreductase 1 (hNQO1) is an attractive enzyme for
cancer therapeutics due to its significant overexpression in tumors compared to healthy …

In recent years, many activatable fluorescent probes have been developed for hNQO1
detection. However, most of the reported fluorescent probes are susceptible to the …

Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based
probes for imaging NAD (P) H: quinone oxidoreductase (NQO1) in cancer cells and tumour …