Alkene functionalisation is a powerful strategy that has enabled access to a wide array of
compounds including valuable pharmaceuticals and agrochemicals. The reactivity of the …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Molecular syntheses largely rely on time‐and labour‐intensive prefunctionalization
strategies. In contrast, C− H activation represents an increasingly powerful approach that …

Alkylation reactions represent an important organic transformation to form C–C bonds. In
addition to conventional approaches with alkyl halides or sulfonates as alkylating agents …

The distant and selective activation of unreactive C–H and C–C bonds remains one of the
biggest challenges in organic chemistry. In recent years, the development of remote …

The emergence of N-heterocyclic carbenes as ligands across the Periodic Table had an
impact on various aspects of the coordination, organometallic, and catalytic chemistry of the …

Exploiting the reactivity of one functional group within a molecule to generate a reaction at a
different position is an ongoing challenge in organic synthesis. Effective remote …

Direct asymmetric functionalization of the pyridyl C–H bond represents a longstanding
challenge in organic chemistry. We herein describe the first enantioselective para-C–H …

Partially fluorinated alkanes, arenes, and alkenes can be transformed by a variety of
transition metal and lanthanide systems. Although the C–H bond is weaker than the C–F …

A mild and regiodivergent aminoalkylation of unactivated alkyl halides is disclosed via a
dual photoredox/nickel catalysis. Bipyridyl-type ligands without an ortho-substituent control …