The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …

Type 2 diabetes has long been thought to have heterogenous causes, even though
epidemiological studies uniformly show a tight relationship with overnutrition. The twin cycle …

Paraphrasing the Swiss physician and father of toxicology Paracelsus (1493–1541) on
chemical agents used as therapeutics,“the dose makes the poison,” it is now realized that …

BACKGROUND. Excessive insulin secretion may lead to glucose dysregulation. Our aim
was to identify primary (independent of insulin resistance) insulin hypersecretion in subjects …

Obesity is the major contributing factor for the increased prevalence of type 2 diabetes (T2D)
in recent years. Sustained positive influx of lipids is considered to be a precipitating factor for …

Context Impaired sensitivity to the antilipolytic action of insulin in adipose tissue (AT) may
play a role in determining metabolic dysfunction in polycystic ovary syndrome (PCOS) …

Aims/hypothesis Our aim was to determine the longitudinal associations of individual NEFA
with the pathogenesis of diabetes, specifically with differences in insulin sensitivity and beta …

In obesity fasting levels of both glucagon and insulin are elevated. In these subjects fasting
levels of the free fatty acid palmitate are raised. We have demonstrated that palmitate …

Cardiovascular disease (CVD) remains a major problem for people with type 2 diabetes
mellitus (T2DM), and dyslipidemia is one of the main drivers for both metabolic diseases. In …

Pharmacological and dietary interventions targeting postprandial glycemia have proved
effective in reducing the risk for type 2 diabetes and its cardiovascular complications …