Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general
population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and …

The sarcomere is an exquisitely designed apparatus that is capable of generating force,
which in the case of the heart results in the pum** of blood throughout the body. At the …

Gene therapy is a promising option for severe forms of genetic diseases. We previously
provided evidence for the feasibility of trans-splicing, exon skip**, and gene replacement …

The heart is an extraordinarily versatile pump, finely tuned to respond to a multitude of
demands. Given the heart pumps without rest for decades its efficiency is particularly …

During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin
filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac …

About half of hypertrophic and dilated cardiomyopathies cases have been recognized as
genetic diseases with mutations in sarcomeric proteins. The sarcomeric proteins are …

Sarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along
with accessory proteins. Thick filaments occupy the center of sarcomeres where they …

Myosin II filaments form ordered superstructures in both cross-striated muscle and non-
muscle cells. In cross-striated muscle, myosin II (thick) filaments, actin (thin) filaments and …

Titin is largely comprised of serially-linked immunoglobulin (Ig) and fibronectin type-III (Fn3)
domains. Many of these domains are arranged in an 11 domain super-repeat pattern that is …

Characterizing the contractile function of human pluripotent stem cell-derived
cardiomyocytes (hPSC-CMs) is key for advancing their utility for cellular disease models …