Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity

A Popov, A Brazhe, P Denisov, O Sutyagina, L Li… - Aging cell, 2021 - Wiley Online Library
Little is known about age‐dependent changes in structure and function of astrocytes and of
the impact of these on the cognitive decline in the senescent brain. The prevalent view on …

Electroacupuncture prevents astrocyte atrophy to alleviate depression

SS Lin, B Zhou, BJ Chen, RT Jiang, B Li, P Illes… - Cell death & …, 2023 - nature.com
Astrocyte atrophy is the main histopathological hallmark of major depressive disorder (MDD)
in humans and in animal models of depression. Here we show that electroacupuncture …

Aberrant calcium signals in reactive astrocytes: a key process in neurological disorders

E Shigetomi, K Saito, F Sano, S Koizumi - International journal of …, 2019 - mdpi.com
Astrocytes are abundant cells in the brain that regulate multiple aspects of neural tissue
homeostasis by providing structural and metabolic support to neurons, maintaining synaptic …

[HTML][HTML] Astrocyte-neuron circuits in epilepsy

BS Purnell, M Alves, D Boison - Neurobiology of disease, 2023 - Elsevier
The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

A Verkhratsky, M Augusto-Oliveira, A Pivoriūnas… - … -European Journal of …, 2021 - Springer
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

Ordinal patterns-based methodologies for distinguishing chaos from noise in discrete time series

M Zanin, F Olivares - Communications Physics, 2021 - nature.com
One of the most important aspects of time series is their degree of stochasticity vs. chaoticity.
Since the discovery of chaotic maps, many algorithms have been proposed to discriminate …

Astroglial atrophy in Alzheimer's disease

A Verkhratsky, JJ Rodrigues, A Pivoriunas… - … -European Journal of …, 2019 - Springer
Astrocytes, a class of morphologically and functionally diverse primary homeostatic
neuroglia, are key keepers of neural tissue homeostasis and fundamental contributors to …

Synaptic pruning by microglia in epilepsy

M Andoh, Y Ikegaya, R Koyama - Journal of clinical medicine, 2019 - mdpi.com
Structural and functional collapse of the balance between excitatory (E) and inhibitory (I)
synapses, ie, synaptic E/I balance, underlies the pathogeneses of various central nervous …