Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an
essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3 …

The Rho family of GTPases (members of the Ras superfamily) are best known for their roles
in regulating cytoskeletal dynamics. It is also well established that misregulation of Rho …

There exists a need for robust approaches for tandem mass spectrometry (MS/MS)-based
identification of proteins in formalin-fixed paraffin-embedded (FFPE) material. We …

Background The influence of the small Rho GTPase Rif (RHOF) on tumor growth, glycolysis,
endothelial–mesenchymal transition (EMT), and the potential mechanism of RHOF in …

Limited studies have explored novel pancreatic cancer (PC) subtypes or prognostic
biomarkers based on the altered activity of relevant signaling pathway gene sets. Here, we …

The highly refractory nature of pancreatic cancer (PC) to chemotherapeutic drugs is one of
the key reasons contributing to the poor prognosis of this disease. MicroRNAs (miRNAs) are …

ABSTRACT The Rho GTPases were discovered more than 30 years ago, and they were for
a long time considered to follow simple cycling between GDP-bound and GTP-bound …

Consumption of a high-fat diet has been associated with an increased risk of develo**
colorectal cancer (CRC). However, the effects of the interaction between dietary fat content …

Abstract Atypical Rho GTPases are a subtype of the Rho GTPase family that are involved in
diverse cellular processes. The typical Rho GTPases, led by RhoA, Rac1 and Cdc42, have …