Regulation of microtubule dynamics, mechanics and function through the growing tip

NB Gudimchuk, JR McIntosh - Nature reviews Molecular cell biology, 2021 - nature.com
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Mechanisms of microtubule organization in differentiated animal cells

A Akhmanova, LC Kapitein - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

[HTML][HTML] The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Microtubule dynamics: an interplay of biochemistry and mechanics

GJ Brouhard, LM Rice - Nature reviews Molecular cell biology, 2018 - nature.com
Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC

D Rai, Y Song, S Hua, K Stecker, JL Monster, V Yin… - Nature Cell …, 2024 - nature.com
Abstract γ-Tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After
nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins …

The mechanism of acentrosomal spindle assembly in human oocytes

T Wu, J Dong, J Fu, Y Kuang, B Chen, H Gu, Y Luo… - Science, 2022 - science.org
Meiotic spindle assembly ensures proper chromosome segregation in oocytes. However,
the mechanisms behind spindle assembly in human oocytes remain largely unknown. We …

Control of microtubule organization and dynamics: two ends in the limelight

A Akhmanova, MO Steinmetz - Nature reviews Molecular cell biology, 2015 - nature.com
Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Mitotic spindle assembly in animal cells: a fine balancing act

SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin

JB Woodruff, BF Gomes, PO Widlund, J Mahamid… - Cell, 2017 - cell.com
Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

Fungal morphogenesis, from the polarized growth of hyphae to complex reproduction and infection structures

M Riquelme, J Aguirre, S Bartnicki-García… - Microbiology and …, 2018 - journals.asm.org
Filamentous fungi constitute a large group of eukaryotic microorganisms that grow by
forming simple tube-like hyphae that are capable of differentiating into more-complex …