For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

Simple Summary One of the important efforts in the treatment of cancers is to achieve
targeted drug delivery by nanocarriers to be more effective and reduce adverse effects …

Cancer cells constantly face a fluctuating nutrient supply and interference with adaptive
responses might be an effective therapeutic approach. It has been discovered that in the …

Advances in immunotherapy have revolutionized the treatment of multiple cancers.
Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of …

The incidence of brain metastases has markedly increased in the past 20 years owing to
progress in the treatment of malignant solid tumours, earlier diagnosis by MRI and an …

Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue
and primarily occur in the brain. Low‐grade tumors of World Health Organization (WHO) …

Targeting neovascularization in glioblastoma (GBM) is hampered by poor understanding of
the underlying mechanisms and unclear linkages to tumour molecular landscapes. Here we …

Tumor normalization strategies aim to improve tumor blood vessel functionality (ie,
perfusion) by reducing the hyper-permeability of tumor vessels or restoring compressed …