Studies on synaptic plasticity in the context of learning have been dominated by the view
that a single, particular type of plasticity forms the underlying mechanism for a particular type …

Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and
memory. Accumulating evidence suggests that glia participates in sculpting the neuronal …

Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological
characteristics have traditionally been considered to be homogeneous. In this study, we …

Acquisition, analysis and simulation of electrophysiological properties of the nervous system
require multiple software packages. This makes it difficult to conserve experimental …

Initial investigations of the cerebellar microcircuit inspired the Marr–Albus theoretical
framework of cerebellar function. We review recent developments in the experimental …

Although our ability to store semantic declarative information can nowadays be readily
surpassed by that of simple personal computers, our ability to learn and express procedural …

Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been
proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have …

Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein
SHANK2 are a highly penetrant cause of autism spectrum disorders (ASD) involving …

Three decades of electrophysiological research on cerebellar cortical activity underlying
Pavlovian conditioning have expanded our understanding of motor learning in the brain …