Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data
The blood–brain barrier (BBB) excludes the vast majority of cancer therapeutics from normal
brain. However, the importance of the BBB in limiting drug delivery and efficacy is …
brain. However, the importance of the BBB in limiting drug delivery and efficacy is …
Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
Current and future trends on diagnosis and prognosis of glioblastoma: from molecular biology to proteomics
Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …
system. Due to the absence of effective pharmacological and surgical treatments, the …
Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma
Purpose: Glioblastoma is the most frequent and lethal primary brain tumor. Development of
novel therapies relies on the availability of relevant preclinical models. We have established …
novel therapies relies on the availability of relevant preclinical models. We have established …
The 2019 mathematical oncology roadmap
Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology,
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …
The biology and mathematical modelling of glioma invasion: a review
JCL Alfonso, K Talkenberger… - Journal of the …, 2017 - royalsocietypublishing.org
Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …
limited life expectancy. The most important hallmark of this type of tumour is its invasive …
Imaging of intratumoral heterogeneity in high-grade glioma
Abstract High-grade glioma (HGG), and particularly Glioblastoma (GBM), can exhibit
pronounced intratumoral heterogeneity that confounds clinical diagnosis and management …
pronounced intratumoral heterogeneity that confounds clinical diagnosis and management …
Biologically-informed neural networks guide mechanistic modeling from sparse experimental data
Biologically-informed neural networks (BINNs), an extension of physics-informed neural
networks, are introduced and used to discover the underlying dynamics of biological …
networks, are introduced and used to discover the underlying dynamics of biological …
Improving cancer treatments via dynamical biophysical models
Despite significant advances in oncological research, cancer nowadays remains one of the
main causes of mortality and morbidity worldwide. New treatment techniques, as a rule …
main causes of mortality and morbidity worldwide. New treatment techniques, as a rule …
Integration of machine learning and mechanistic models accurately predicts variation in cell density of glioblastoma using multiparametric MRI
Glioblastoma (GBM) is a heterogeneous and lethal brain cancer. These tumors are followed
using magnetic resonance imaging (MRI), which is unable to precisely identify tumor cell …
using magnetic resonance imaging (MRI), which is unable to precisely identify tumor cell …