Antibacterial pyrazoles: Tackling resistant bacteria

MA Alam - Future Medicinal Chemistry, 2022 - Taylor & Francis
Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine,
food production and ultimately life expectancy. Antibiotic resistance is a global concern …

[HTML][HTML] The bioactivity of benzenesulfonyl hydrazones: A short review

Ł Popiołek - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The synthesis and biological activity evaluation of benzenesulfonyl hydrazones is quite
frequently encountered in scientific literature. This class of compounds is very interesting …

Aloe emodin-conjugated sulfonyl hydrazones as novel type of antibacterial modulators against S. aureus 25923 through multifaceted synergistic effects

Z Deng, RRY Bheemanaboina, Y Luo, CH Zhou - Bioorganic Chemistry, 2022 - Elsevier
Aloe emodin-conjugated sulfonyl hydrazones were designed and synthesized as novel type
of antibacterial modulators. Aloe emodin benzenesulfonyl hydrazone 5a (AEBH-5a) was …

Development of new antimycobacterial sulfonyl hydrazones and 4-methyl-1, 2, 3-thiadiazole-based hydrazone derivatives

VT Angelova, T Pencheva, N Vassilev, E K-Yovkova… - Antibiotics, 2022 - mdpi.com
Fifteen 4-methyl-1, 2, 3-thiadiazole-based hydrazone derivatives 3a–d and sulfonyl
hydrazones 5a–k were synthesized. They were characterized by 1H-NMR, 13C NMR, and …

Hydrazinosulfonylation of aryl electrophiles: a straightforward approach for the synthesis of aryl N-aminosulfonamides

CY Hsu, AKO Aldulaimi, H Bahir, AH Adhab… - RSC …, 2023 - pubs.rsc.org
In recent years, the direct hydrazinosulfonylation of aryl electrophiles with SO2 and
hydrazines has emerged as an efficient and versatile method for the synthesis of aryl N …

Linking quinoline ring to 5-nitrofuran moiety via sulfonyl hydrazone bridge: Synthesis, structural characterization, DFT studies, and evaluation of antibacterial and …

ŞD Doğan, E Özcan, Y Çetinkaya, Mİ Han… - Journal of Molecular …, 2023 - Elsevier
In the present work, we report the synthesis, structural characterization, and computational
studies of (E)-N'-((5-nitrofuran-2-yl) methylene) quinoline-8-sulfonohydrazide (QNF) as a …

Design, synthesis and mechanistic studies of benzophenones hydrazone derivatives as cathepsin inhibitors

IA Abdel-Azziz, NH Amin, MT El-Saadi… - Journal of Molecular …, 2023 - Elsevier
A novel series of benzophenone hydrazone derivatives were synthesized and evaluated for
their antiproliferative activity. The thiosemicarbazone derivative 5c and guanylhydrazone …

Synthesis, anti-ferroptosis, anti-quorum sensing, antibacterial and DNA interaction studies of chromene-hydrazone derivatives

AJ Ressler, M Frate, A Hontoria, A Ream… - Bioorganic & medicinal …, 2023 - Elsevier
Nineteen chromene-hydrazone derivatives containing a variety of structural modifications on
the hydrazone moiety were synthesized. Structure-activity correlations were investigated to …

[HTML][HTML] Approachable Synthetic Methodologies for Second-Generation β-Lactamase Inhibitors: A Review

N Fatima, S Khalid, N Rasool, M Imran, B Parveen… - Pharmaceuticals, 2024 - mdpi.com
Some antibiotics that are frequently employed are β-lactams. In light of the hydrolytic
process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) …

Fungal secondary metabolites/dicationic pyridinium iodide combinations in combat against multi-drug resistant microorganisms

AM Abdelalatif, BH Elwakil, MZ Mohamed, M Hagar… - Molecules, 2023 - mdpi.com
The spread of antibiotic-resistant opportunistic microbes is a huge socioeconomic burden
and a growing concern for global public health. In the current study, two endophytic fungal …