Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …

Abstract Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme
involved in glycogen metabolism, but is now known to regulate a diverse array of cell …

Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …

Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3
(GSK3) is now a well-established component of the Wnt signalling pathway, which is …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as
neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under …

Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase
that plays a key role in the pathogenesis of Alzheimer's disease (AD). GSK3 phosphorylates …

In neurons, Glycogen Synthase Kinase‐3β (GSK‐3β) has been shown to regulate various
critical processes underlying structural and functional synaptic plasticity. Mouse models with …