The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection

SH Safiabadi Tali, JJ LeBlanc, Z Sadiq… - Clinical microbiology …, 2021 - journals.asm.org
SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory disease coronavirus 2 (SARS-CoV-2), has led to millions of confirmed cases and …

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

YJ Park, D Pinto, AC Walls, Z Liu, A De Marco… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …

Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study

P Naaber, L Tserel, K Kangro, E Sepp… - The Lancet Regional …, 2021 - thelancet.com
ABSTRACT Background SARS-CoV-2 mRNA vaccines have proven high efficacy, however,
limited data exists on the duration of immune responses and their relation to age and side …

[HTML][HTML] Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

S Afkhami, MR D'Agostino, A Zhang, HD Stacey… - Cell, 2022 - cell.com
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …

[HTML][HTML] Adaptive immunity to SARS-CoV-2 and COVID-19

A Sette, S Crotty - Cell, 2021 - cell.com
The adaptive immune system is important for control of most viral infections. The three
fundamental components of the adaptive immune system are B cells (the source of …

[HTML][HTML] Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study

PY Chia, SWX Ong, CJ Chiew, LW Ang… - Clinical microbiology …, 2022 - Elsevier
Objectives Highly effective vaccines against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) have been developed but variants of concerns are worrisome, especially B …

[HTML][HTML] Map** neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

L Piccoli, YJ Park, MA Tortorici, N Czudnochowski… - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-
CoV-2 infection is crucial for understanding immune protection and identifying targets for …

Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

Y Zhong, AYH Kang, CJX Tay, HE Li, N Elyana… - Nature medicine, 2024 - nature.com
The paucity of information on longevity of vaccine-induced immune responses and
uncertainty of the correlates of protection hinder the development of evidence-based COVID …

[HTML][HTML] Circular RNA vaccines against SARS-CoV-2 and emerging variants

L Qu, Z Yi, Y Shen, L Lin, F Chen, Y Xu, Z Wu, H Tang… - Cell, 2022 - cell.com
As the emerging variants of SARS-CoV-2 continue to drive the worldwide pandemic, there is
a constant demand for vaccines that offer more effective and broad-spectrum protection …