Autoantibodies targeting G-protein-coupled receptors: pathogenetic, clinical and therapeutic implications in systemic sclerosis

M Binda, B Moccaldi, G Civieri, A Cuberli… - International Journal of …, 2024 - mdpi.com
Systemic sclerosis (SSc) is a multifaceted connective tissue disease whose aetiology
remains largely unknown. Autoimmunity is thought to play a pivotal role in the development …

Acute rejection in the modern lung transplant era

B Renaud-Picard, A Koutsokera… - … in Respiratory and …, 2021 - thieme-connect.com
Acute cellular rejection (ACR) remains a common complication after lung transplantation.
Mortality directly related to ACR is low and most patients respond to first-line …

Lung Transplant Immunomodulation with Genetically Engineered Mesenchymal Stromal Cells—Therapeutic Window for Interleukin-10

AI Nykänen, A Mariscal, A Duong, A Ali, A Takahagi… - Cells, 2024 - mdpi.com
Lung transplantation results are compromised by ischemia–reperfusion injury and
alloimmune responses. Ex vivo lung perfusion (EVLP) is used to assess marginal donor …

Multi-omics profiling predicts allograft function after lung transplantation

ML Watzenboeck, AD Gorki… - European …, 2022 - publications.ersnet.org
Rationale Lung transplantation is the ultimate treatment option for patients with end-stage
respiratory diseases but bears the highest mortality rate among all solid organ …

Diminazen aceturate protects pulmonary ischemia-reperfusion injury via inhibition of ADAM17-mediated angiotensin-converting enzyme 2 shedding

LF Wang, YY Sun, Q Pan, YQ Yin, XM Tian… - Frontiers in …, 2021 - frontiersin.org
Lung ischemia-reperfusion (IR) injury is induced by pulmonary artery occlusion and
reperfusion. Lung IR injury commonly happens after weaning from extracorporeal …

Acute cellular rejection: is it still relevant?

A Koutsokera, L Levy, P Pal… - … in respiratory and …, 2018 - thieme-connect.com
Despite significant progress in the field of transplant immunology, acute cellular rejection
(ACR) remains a very frequent complication after lung transplantation (LTx), with almost …

Lung allograft rejection

DJ Levine, RR Hachem - Thoracic surgery clinics, 2022 - thoracic.theclinics.com
Lung transplantation is the best therapeutic option for many patients with end-stage lung
diseases for which there are no other available therapies. The 2019 International Society for …

Role of mast cells and type 2 innate lymphoid (ILC2) cells in lung transplantation

E Mortaz, S Amani, S Mumby, IM Adcock… - Journal of …, 2018 - Wiley Online Library
The multifunctional role of mast cells (MCs) in the immune system is complex and has not
fully been explored. MCs reside in tissues and mucous membranes such as the lung …

FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

S Shrestha, W Cho, B Stump, J Imani, AM Lamattina… - Molecular …, 2020 - Springer
Background Therapeutic lymphangiogenesis in an orthotopic lung transplant model has
been shown to improve acute allograft rejection that is mediated at least in part through …

[HTML][HTML] Intermittent exposure of hypercapnia suppresses allograft rejection via induction of Treg differentiation and inhibition of neutrophil accumulation

YS Tzeng, YJ Peng, SE Tang, KL Huang, SJ Chu… - Biomedicines, 2022 - mdpi.com
Background: In the management of major burn wounds, allogeneic skin transplantation is a
critical procedure to improve wound repair. Our previous works found that intermittent …