Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the
United States. The annual incidence of primary malignant brain tumors is approximately 7 …

A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

Primary CNS tumours refer to a heterogeneous group of tumours arising from cells within the
CNS, and can be benign or malignant. Malignant primary brain tumours remain among the …

Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …

Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …

Gliomas are the most frequent intrinsic tumours of the central nervous system and
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …

Central nervous system tumours represent one of the most lethal cancer types, particularly
among children. Primary treatment includes neurosurgical resection of the tumour, in which …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Study of the origin and development of cerebellar tumours has been hampered by the
complexity and heterogeneity of cerebellar cells that change over the course of …

Brain tumors are the most common solid tumors in children, and, unfortunately, many
subtypes continue to have a suboptimal long-term outcome. During the last several years …