The intense world theory–a unifying theory of the neurobiology of autism
Autism covers a wide spectrum of disorders for which there are many views, hypotheses and
theories. Here we propose a unifying theory of autism, the Intense World Theory. The …
theories. Here we propose a unifying theory of autism, the Intense World Theory. The …
Autism spectrum disorder: focus on glutamatergic neurotransmission
Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …
A synaptic organizing principle for cortical neuronal groups
Neuronal circuitry is often considered a clean slate that can be dynamically and arbitrarily
molded by experience. However, when we investigated synaptic connectivity in groups of …
molded by experience. However, when we investigated synaptic connectivity in groups of …
Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder
AM Tartaglione, S Schiavi, G Calamandrei, V Trezza - Neuropharmacology, 2019 - Elsevier
Impairments in social interaction and verbal and non verbal communication are among the
main features of Autism Spectrum Disorder (ASD). The causes of ASD are still unknown but …
main features of Autism Spectrum Disorder (ASD). The causes of ASD are still unknown but …
General developmental health in the VPA-rat model of autism
MR Favre, TR Barkat, D LaMendola… - Frontiers in behavioral …, 2013 - frontiersin.org
Autism is a neurodevelopmental condition diagnosed by impaired social interaction,
abnormal communication and, stereotyped behaviors. While post-mortem and imaging …
abnormal communication and, stereotyped behaviors. While post-mortem and imaging …
Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism
The biological mechanisms of autism spectrum disorders (ASDs) are largely unknown in
spite of extensive research. ASD is characterized by altered function of multiple brain areas …
spite of extensive research. ASD is characterized by altered function of multiple brain areas …
Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder
ME Bringas, FN Carvajal-Flores, TA López-Ramírez… - Neuroscience, 2013 - Elsevier
Valproic acid (VPA) is a blocker of histone deacetylase widely used to treat epilepsy, bipolar
disorders, and migraine; its administration during pregnancy increases the risk of autism …
disorders, and migraine; its administration during pregnancy increases the risk of autism …
Abnormal development of the earliest cortical circuits in a mouse model of autism spectrum disorder
Autism spectrum disorder (ASD) involves deficits in speech and sound processing. Cortical
circuit changes during early development likely contribute to such deficits. Subplate neurons …
circuit changes during early development likely contribute to such deficits. Subplate neurons …
The role of zinc and NMDA receptors in autism spectrum disorders
NMDA-type glutamate receptors are critical for synaptic plasticity in the central nervous
system. Their unique properties and age-dependent arrangement of subunit types underpin …
system. Their unique properties and age-dependent arrangement of subunit types underpin …
Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors
J Kang, E Kim - Frontiers in molecular neuroscience, 2015 - frontiersin.org
Animals prenatally exposed to valproic acid (VPA), an antiepileptic agent, have been used
as a model for autism spectrum disorders (ASDs). Previous studies have identified …
as a model for autism spectrum disorders (ASDs). Previous studies have identified …