Enzyme engineering plays a central role in develo** efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …

Bgee is a database to retrieve and compare gene expression patterns in multiple animal
species, produced by integrating multiple data types (RNA-Seq, Affymetrix, in situ …

Abstract The Gene Ontology (GO) is a formidable resource, but there are several
considerations about it that are essential to understand the data and interpret it correctly …

Nucleotide and protein sequences stored in public databases are the cornerstone of many
bioinformatics analyses. The records containing these sequences are prone to a wide range …

Abstract The Evidence and Conclusion Ontology (ECO) contains terms (classes) that
describe types of evidence and assertion methods. ECO terms are used in the process of …

Knowledge about the substrate scope for a given enzyme is informative for elucidating
biochemical pathways and also for expanding applications of the enzyme. However, no …

Background: The continual evolution of the world is closely chaperoned by the emergence
of deadly diseases, which presents itself at every turn thus determining the 3D structure of a …

Gene duplication followed by mutation is a classic mechanism of neofunctionalization,
producing gene families with functional diversity. In some cases, a single point mutation is …

Deguelin is a major active ingredient and principal component in several plants and it is a
potential molecule to target proteins of cancer cell signaling pathway. As a complex natural …

Most of the birds's adaptations for migration have a neuroendocrine origin, triggered by
changes in photoperiod and the patterns of Earth's magnetic field. Migration …