[HTML][HTML] Hypoxia and brain aging: Neurodegeneration or neuroprotection?
The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase
RA DeBose-Boyd - Cell research, 2008 - nature.com
Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, an
important intermediate in the synthesis of cholesterol and essential nonsterol isoprenoids …
important intermediate in the synthesis of cholesterol and essential nonsterol isoprenoids …
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
DJ Manalo, A Rowan, T Lavoie, L Natarajan, BD Kelly… - Blood, 2005 - ashpublications.org
Abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding
angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial …
angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial …
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
S Kume, T Uzu, K Horiike… - The Journal of …, 2010 - Am Soc Clin Investig
Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the …
demonstrate that this process is attenuated by calorie restriction (CR). However, the …
[HTML][HTML] Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers
Chronic age-related degenerative disorders, including the formation of chronic leg wounds,
may occur due to aging of the stromal tissues and ensuing dysfunctional cellular responses …
may occur due to aging of the stromal tissues and ensuing dysfunctional cellular responses …
[HTML][HTML] Modeling colon adenocarcinomas in vitro: A 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction
Activated tumor stroma participates in tumor cell growth, invasion, and metastasis. Normal
fibroblasts and cancer-associated fibroblasts (CAFs) have been shown to display distinct …
fibroblasts and cancer-associated fibroblasts (CAFs) have been shown to display distinct …
Hypoxia signaling in parkinson's disease: There is use in asking “What HIF?”
Simple Summary Parkinson's disease is a neurodegenerative disorder characterized by the
death of a specific subset of dopamine-producing neurons. This triggers problems with …
death of a specific subset of dopamine-producing neurons. This triggers problems with …
Lower skeletal muscle capillarization and VEGF expression in aged vs. young men
Recently, we observed that muscle capillarization, vascular endothelial growth factor (VEGF)
protein, and the VEGF mRNA response to acute exercise were lower in aged compared with …
protein, and the VEGF mRNA response to acute exercise were lower in aged compared with …
Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated …
AD Nguyen, JG McDonald, RK Bruick… - Journal of Biological …, 2007 - ASBMB
Endoplasmic reticulum-associated degradation of the enzyme 3-hydroxy-3-methylglutaryl-
CoA reductase represents one mechanism by which cholesterol synthesis is controlled in …
CoA reductase represents one mechanism by which cholesterol synthesis is controlled in …
Beaver and naked mole rat genomes reveal common paths to longevity
Long-lived rodents have become an attractive model for the studies on aging. To understand
evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two …
evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two …